Cryocooler for Cryopreservation:
Our BIOSAFE® liquid nitrogen freezer
The BIOSAFE® Cryocooler from Cryotherm has long been a byword for quality and safety. Experience, technology and our know-how make your decision for the cryocooler BIOSAFE® easy. With various sizes and designs of BIOSAFE®, CRYOTHERM offers the complete solution for all cryopreservation tasks.
Standard equipment —
BIOSAFE®
Cryopreservation of cryogenic liquefied nitrogen is proven practice in science, research, medicine, environmental research and technology. The safe cold down to -190 °C in the gas phase and the inert atmosphere enable optimum freezing and storage of valuable medical and biological samples and materials.
With different sizes and designs of BIOSAFE®, supplemented by a wide range of accessories, CRYOTHERM offers the complete solution for your cryopreservation tasks:
- controlled and programmed freezing of your samples in freezers
- Administration and backup of your sample data by the sample management system
- supply system for the cryogenic liquefied nitrogen via APOLLO®-supply tanks, optimised to your requirements
- or directly supplied from a super insulated transfer line
- the orderly, safe packaging and classification of the samples using the BIOSAFE® classification system
- Remote monitoring of your samples by the remote monitoring system CRYO-MESSENGER®
*applies to BIOSAFE® 220/420
Unverwechselbar & ausgefeilt*:
Ergonomischer Hub-/Schwenkmechanismus/ Niedrige, bedienerfreundliche Behälterhöhe.
Doppelt gesichert!
Mechanisch und optional elektronisch verriegelbarer Deckel.
En détail durchdacht:
Hohe Stickstoffreserve unter dem Stellboden reicht je nach Behältergröße für mehrere Tage.
Hohe Lagerkapazität
Für bis zu 23.100 Proben 2ml Ampullen.
Perfekt zu desinfizieren
glatte Oberflächen - auch am Deckel
Niedrige Verdampfungsraten
maximal 2,3%/Tag, gemessen bei Gasphasenlagerung
Optimierte Lagerkapazität
durch Einsatz von platzsparenden High-Efficiency-Einordnungssystemen.
TOP-Zugänglichkeit
zu den Proben, ideal für den regelmäßigen Einsatz
Dem Markt voraus:
Die integrierte BIOSAFE® smart-Steuerung als Füllstandsregelung und Behälterüberwachung
BIOSAFE® images.
Freezing & storage of
large sample quantities
The Cryocooler BIOSAFE® refrigerator systems 120 to 420 are optimized for maximum capacity with minimized external dimensions to reach temperature below -169°C / -272,2°F / 104,15K. The large, thermodynamically improved, vacuum-insulated lid in an attractive design allows access to stored materials in seconds.
Cryocooler BIOSAFE® systems 500 to 2400 are optimized for maximum capacity with minimized consumption. In the range 500 litres to 2400 litres and more, the containers can be easily loaded via the side-mounted container neck and the smooth-running carousel. The smooth-running castors make BIOSAFE® storage containers mobile and now even more flexible. Cryo cooling at ultra low temperatures is nowadays more important than ever before. Most of the time cryocoolers like our BIOSAFE® use a cryogenic fluid as the working substance.
The thermodynamic cycle is fed with nitrogen. At room temperature, the liquid nitrogen is typically compressed, precooled in a heat exchanger, and then expanded at a low temperature. The returning low-pressure fluid passes through the heat exchanger to pre-cool the high-pressure fluid before entering the compressor inlet. The cycle is then repeated.
For the cooling of superconducting magnets (cryogenic refrigerators) you should also get in contact with us. We have or we create solutions for any cryo related problems.
| designation | BIOSAFE® 120 | BIOSAFE® 220 | BIOSAFE® 420 | BIOSAFE® 500 | BIOSAFE® 800 | BIOSAFE® 2400 |
| 2 ml ampoules in drawers (Ø 12mm) | 6750 | 13000 | 23100 | 26260 | 43120 | 120000 |
| 2 ml ampoules in cryoboxes (Ø 12mm) | 7000 | 13000 | 21750 | 22750 | ||
| 5 ml ampoules in drawers (Ø 12mm) | 3375 | 6500 | 11550 | 12120 | ||
| freezer bag (50ml)* Baxter 4R9951/Miltenyi AND 2ml ampoules (Ø 12mm) in drawers | 288 - | 512 - | 832 1500 | on request - | on request | on request |
| freezer bags (500ml)* Baxter 4R9955/Miltenyi AND 2ml ampoules (Ø 12mm) in drawers | 144 500 | 240 1500 | 480 500 | 480 - | on request | on request |
| freezer bags (500ml)* Hempfreeze/Gambro Z2003 AND 2ml ampoules (Ø 12mm) in drawers | 75 750 | 150 500 | 270 500 | on request - | on request | on request |
*other bag manufacture and types on request
Benefits:
- Nitrogen reserve under the adjustable bottom is sufficient for up to two weeks, depending on the size of the tank for cooling even after an occuring failure
- Redundant hardware for software-independent monitoring of minimum alarm and maximum alarm
- Low temperatures of -180°C, whether for small or large tanks and whether for wide-neck tanks or tanks with carousel
- Remote diagnosis and remote monitoring
- Medcert certified
- Very low evaporation rate
- Full storage capacity for gas phase storage
- Integrated level control device and container monitoring system BIOSAFE® CONTROL ß
- Stainless steel design
- Service for commissioning and execution of qualifications (IQ/OQ)
Technical data of the
BIOSAFE® series:
| container designation | BIOSAFE® 120 | BIOSAFE® 220 | BIOSAFE® 420 | BIOSAFE® 500 | BIOSAFE® 800 | BIOSAFE® 2400 |
| vessel material | stainless steel | stainless steel | stainless steel | stainless steel | stainless steel | stainless steel |
| content, geometric (l) | 151 | 251 | 420 | 490 | 960 | 2400 |
| content, geometrically below the adjustable floor (l) | 21 | 35 | 57 | 50 | 117 | 300 |
| weight, empty (kg) | 100 | 175 | 225 | 320 | 570 | 1300 |
| outer diameter (mm) | 560 | 710 | 900 | 890 | 1058 | 1650 |
| Inside diameter (mm) | 514 | 664 | 854 | 795 | 966 | 1500 |
| neck diameter (mm) | 514 | 664 | 854 | 450 | 520 | 830 |
| Total height (mm) | 1140/1045 | 1180/1070 | 1190/1070 | 1314/1014 | 1800/1380 | 2100/2100 |
| Adjustment height (mm) | 625 | 625 | 625 | 800 | 800 | 915 |
| Roll diameter (mm) | - | 80 | 80 | 80 | 80 | 100 |
| Evaporation rate, statistical (%/day) | 2.3 | 2.0 | 1.5 | 1.2 | 0.9 | 0.6 |
Options
- Other container sizes
- Redundant fill level and container monitoring system
- Connection via Ethernet
- I/O box with relays
- Remote monitoring via SMS, e-mail & Co.
- BIOSAFE® rack systems
Certificates
Cryocooler for Cryopreservation: Our BIOSAFE® liquid nitrogen freezer
The BIOSAFE® Cryocooler from Cryotherm has long been a byword for quality and safety. Experience, technology and our know-how make your decision for the cryocooler BIOSAFE® easy. With various sizes and designs of BIOSAFE®, CRYOTHERM offers the complete solution for all cryopreservation tasks.